DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
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چکیده
منابع مشابه
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.
DYRK1A is a dual-specificity protein kinase that autophosphorylates a conserved tyrosine residue in the activation loop but phosphorylates exogenous substrates only at serine or threonine residues. Tyrosine autophosphorylation of DYRKs is a one-off event that takes place during translation and induces the activation of the kinase. Here we characterize the beta-carboline alkaloid harmine as a po...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2008
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2008.06751.x